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Each component reinforces the others

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

Because topical rapamycin can make skin more sensitive to sunlight, apply SPF 30+ daily and avoid excessive sun exposure

This is due to wide variations in absorption rates

In parallel, Zhao et al